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Interestingly, by comparing ROS expression in both wound healing (early stage, lower levels) and regeneration (later stage, elevated levels) in planarians, Van Huizen et al

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Tretinoin reliably produces what dermatologists call retinoid dermatitis or the 'retinization' period during the first two to eight weeks: redness, flaking, dryness, stinging, and sometimes a temporary flare of breakouts

Dubois M, Claeys H, Van Den Broeck L, Inz D (2017) Time of day determines Arabidopsis transcriptome and growth dynamics under mild drought

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And iron is a cofactor for enzymes involved in DNA repair, which may curb disease risk, and is needed to launch effective immune responses to pathogens